Formulation Development and Evaluation of Diclofenac Sodium Sustained Release Tablet Using Factorial Design.

Preparation and Evaluation of Sustained Release Matrix Tablet of Diclofenac Sodium using Natural Polymer

Sustained release tablets of Diclofenac Sodium were fabricated using Cashew nut tree gum, HPMC and Carbopol . The tablets were evaluated for preformulation studies like angle of repose, bluk density, compressibility index and physical characteristics like hardness, weight variation, fraibilty and drug content. In-vitro release of drug was performed in PBS pH 7.2 for twelve hours. All the physic...

Formulation and Evaluation of Diclofenac Sodium Sustained Release Tablets Using Melt Granulation Technique

Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where...

Formulation and Optimization of Sustained Release Tablets of Diclofenac Sodium Using Guar Gum as Release Modifier

PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ra...

Formulation and Evaluation of Sustained Release Pellets of Tramadol HCl Using 3 Full Factorial Design

The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Development of sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeuti...

formulation and physicochemical evaluation of sustained release diclofenac sodium ocular film